One day
Take the day slowly for the altitude. Tour the Casa Nacional de la Moneda for the story of the silver and the empire, then see the colonial churches — San Lorenzo's carved façade, the cathedral, San Francisco — and the mansions around the Plaza 10 de Noviembre. Have a warming highland lunch (salteñas, a hearty soup), and spend the afternoon at the miners' market and taking in the Cerro Rico's presence over the city, or the convent of Santa Teresa. Rest well in the cold evening.