Santa Catalina Monastery — Arequipa's jewel is the Santa Catalina Monastery, a walled convent founded in the 16th century that grew into a self-contained citadel — a maze of narrow lanes, plazas, cloisters and cells painted in deep blue, russet and ochre, where cloistered nuns lived for centuries. Wandering its silent, colour-washed streets, kitchens and courtyards is like stepping into a miniature secret city, and it's one of the most extraordinary sights in Peru. Give it a couple of unhurried hours; it's the essential Arequipa experience.
The White City in sillar — Arequipa's colonial centre glows because it's built from sillar, a pale volcanic stone quarried from the surrounding mountains, carved into ornate Baroque façades — nowhere finer than the intricately worked front of the Jesuit church of La Compañía. Around the grand arcaded Plaza de Armas and its cathedral, the white streets and palaces have a luminous quality unique in Peru. Wander the centre, look up at the carved stone, and, at the Juanita museum, see the remarkably preserved "ice mummy" of an Inca girl found on a nearby volcano.
Arequipan food — Arequipa is proud of its cuisine, widely rated among Peru's best, and its picanterías — traditional, hearty restaurants — are institutions. The signature is rocoto relleno (a stuffed, fiery red pepper), alongside adobo (a spiced pork stew, a Sunday-breakfast tradition), chupe de camarones (river-prawn chowder), ocopa (potatoes in a herb-and-peanut sauce), and the queso helado dessert. Eat in a proper picantería, ideally at lunch, for the full regional table, and drink a chicha or a Peruvian beer. The food is a genuine highlight.
Volcanoes and the Colca Canyon — Arequipa's setting is dramatic — three volcanoes ring the city, El Misti's perfect cone the most striking, and adventurous visitors climb them or the surrounding peaks. But the great excursion is the Colca Canyon, a few hours north — one of the world's deepest, a landscape of terraced valleys and Andean villages, where giant condors ride the morning thermals at the famous Cruz del Cóndor viewpoint. A day or overnight trip to Colca is a highlight of the region, and a stunning complement to the city.